70 Movies We Saw in the ’70s: WHAT’S UP DOC (1972) Barbra Streisand and Ryan O’Neal run brilliantly, hilariously berserk through San Francisco’s built-for-slapstick landscape, propelled forth by screwball comedy history, cartoon crack-ups, and director Peter Bogdanovich’s superhuman mastery of controlling chaos. Brooklyn boys Mike McPadden and Ben Reiser are also on the scene and you are, too, as we howl the praises of WHAT’S UP DOC!