As physicians taking care of young girls and women with HMB, we are often faced with a challenging patient who is at a high risk for developing thrombosis due to a family history, a past personal history of thrombosis or medical conditions that could be a trigger for developing blood clots. In this podcast, we will be speaking with our experts on thrombosis and HMB to help us navigate through these difficult decision-making scenarios. We will be referring to certain brand names of hormonal therapies as our listeners are familiar with those rather than the complicated generic nomenclature. We will use gender-neutral language whenever possible, but when discussing the results of clinical studies, we may refer to women or girls because that is the language specifically used by the authors.