It’s a Week 3 showdown in the NFC West as the San Francisco 49ers (2-0) host the Arizona Cardinals (2-0) in a battle of undefeated teams! The 49ers return home for the first time in 2025 after back-to-back road wins and look to defend Levi’s Stadium against Kyler Murray, Marvin Harrison Jr., and a banged-up Arizona secondary.
We break down everything you need to know ahead of this massive NFC West clash:
- How the 49ers defense can pressure Kyler Murray and shut down Arizona’s deep passing attack
- Why Christian McCaffrey could dominate again vs. the Cardinals (1,006 total yards & 10 TDs in 7 games)
- Brock Purdy and Mac Jones’ opportunity to exploit a depleted Cardinals secondary
- Arizona’s new-look defensive front led by Josh Sweat, Calais Campbell, and Dalvin TomlinsonKeys to victory for both teams in the battle for NFC West supremacy
📌 Drop your score predictions in the comments!
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