In the final installment of COVID-19 conversation, Drs. Riley and Vickery discuss vaccine hesitancy. The conversation begins with Dr. Riley laying the ground work for including patients in their medical choices. The conversation then progresses to a discussion of populations in which hesitancy can be understood from a scientific perspective, which may influence one's thoughts on universal mandates. The episode ends with a summary of what Dr. Vickery believes are the key take-home points. Of note, this episode was recorded before the FDA approval of Pfizer's COVID-19 vaccine.